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KMID : 0361020110540020148
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Korean Journal of Otolaryngology - Head and Neck Surgery
2011 Volume.54 No. 2 p.148 ~ p.153
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Voice Characteristics of Adductor Spasmodic Dysphonia before and after Botulinum Toxin-A Injection
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Yun Bo-Ram
Kim Hyang-Hee
Choi Yae-Lin
Choi Hong-Shik
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Abstract
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Background and Objectives : Botulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of “Spasmodic dysphonia”. However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A.
Subjects and Method : The study examined 12 female patients with ‘adductor spasmodic dysphonia’. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale.
Results: Aerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequ-ency distribution was significantly increased, while the mean amplitude and the mean clos-ed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient self-rating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life.
Conclusion: Our results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.
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KEYWORD
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Spasmodic dysphonia, Botulinum toxin, Voice assessment
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